Mexican lasagna combines the rich, hearty layers of traditional Italian lasagna with the bold, spicy flavors of Mexican cuisine. This deeply satisfying dish is perfect for feeding a crowd, preparing in advance, or freezing for later. It’s a weeknight dinner or party favorite that brings the best of both culinary worlds into one cheesy, flavorful casserole.

Layer-by-Layer: Mexican Lasagna Ingredients Breakdown
Key Components:
- Tortilla Layers: Soft corn or flour tortillas replace lasagna noodles for a tender, slightly chewy bite.
- Seasoned Meat Filling: Ground beef or turkey cooked with onions, garlic, and bold taco spices.
- Beans and Corn: Add heartiness and texture.
- Cheese: A blend of melty cheeses like cheddar, Monterey Jack, or queso quesadilla.
- Sauce: Either a red enchilada sauce or a homemade tomato-chili sauce for moisture and spice.
- Toppings: Fresh cilantro, scallions, sour cream, avocado, or pickled jalapeños.
Ingredients List (Serves 6–8)

Meat Filling:
- 1 tbsp olive oil
- 1 lb ground beef or turkey
- 1 small yellow onion, finely chopped
- 2 cloves garlic, minced
- 2 tbsp tomato paste
- 2 tsp ground cumin
- 1 ½ tsp chili powder
- 1 tsp paprika
- ½ tsp dried oregano
- ½ tsp salt
- ¼ tsp ground black pepper
Layering:
- 8–10 flour or corn tortillas
- 1 can (15 oz) black beans, rinsed and drained
- 1 cup frozen corn (thawed)
- 1 can (10 oz) diced tomatoes with green chiles (drained)
- 2 cups shredded cheese (Mexican blend or cheddar-Monterey mix)
- 2 cups red enchilada sauce (homemade or store-bought)
Optional Garnish:
- Fresh cilantro
- Sliced green onions
- Diced avocado or guacamole
- Sour cream
- Pickled red onions or jalapeños
Cooking Instructions: Step-by-Step
1. Prepare the Meat Mixture
Heat olive oil in a large skillet over medium heat. Sauté the onion and garlic until translucent. Add the ground meat and cook until browned. Stir in tomato paste and seasonings. Let simmer for 5 minutes to absorb the flavors.
2. Prepare the Baking Dish
Lightly grease a 9×13-inch baking dish. Preheat oven to 375°F (190°C).
3. Assemble the Layers
- Base Layer: Spread a thin layer of enchilada sauce on the bottom.
- First Layer: Add a layer of tortillas (overlapping slightly to cover).
- Second Layer: Spread half of the meat mixture.
- Third Layer: Sprinkle half of the beans, corn, and tomatoes.
- Fourth Layer: Drizzle enchilada sauce and top with cheese.
Repeat the layers once more. Top the final tortilla layer with remaining sauce and a generous layer of cheese.
4. Bake
Cover with foil and bake for 20 minutes. Remove foil and bake an additional 10 minutes until bubbly and golden on top.
5. Rest and Serve
Let the lasagna rest for 10–15 minutes before slicing to allow layers to set. Garnish with fresh toppings.
Customization Ideas for Dietary Preferences

Preference | Modifications |
---|---|
Vegetarian | Replace meat with sautéed mushrooms, zucchini, or a plant-based meat alternative. |
Gluten-Free | Use certified gluten-free corn tortillas and ensure enchilada sauce is gluten-free. |
Low-Carb | Use thin slices of zucchini or eggplant in place of tortillas. |
Dairy-Free | Substitute cheese with a vegan blend and opt for cashew cream as garnish. |
Storage & Freezer Instructions
- Make-Ahead: Assemble fully, cover, and refrigerate up to 24 hours before baking.
- Refrigerate Leftovers: Store in airtight containers for up to 4 days.
- Freeze: Wrap unbaked or baked lasagna in foil and freeze for up to 3 months. Thaw overnight in refrigerator and bake as directed.
Suggested Sides and Pairings
- Cilantro lime rice
- Mexican street corn (elote)
- Refried beans or charro beans
- Fresh pico de gallo or tomato-avocado salad
- Spicy mango margarita or hibiscus agua fresca
Nutritional Estimate Per Serving
Nutrient | Approximate Value |
---|---|
Calories | 420–480 kcal |
Protein | 22–28g |
Carbohydrates | 30–36g |
Fat | 20–25g |
Fiber | 6–8g |
Sodium | 800–950mg |
FAQs

Can I use rotisserie chicken instead of ground meat?
Yes. Shredded chicken is a great substitute. Toss it with spices and tomato paste before layering.
Should I toast tortillas before layering?
Not necessary, but lightly warming them helps prevent tearing during assembly.
Can I double the recipe?
Yes, easily scale up and use two pans. Ideal for meal prep or serving a large group.
What’s the best cheese for melting?
A mix of Monterey Jack, cheddar, and queso quesadilla provides a rich, gooey melt and flavor depth.
Conclusion
This Mexican lasagna is the ultimate fusion of spicy, cheesy, and savory layers that deliver comfort in every bite. It’s endlessly customizable, ideal for freezing, and guaranteed to satisfy. Whether you’re cooking for a crowd or feeding your family, this dish checks every box for ease, flavor, and flair.