Pepperoni Pizza Casserole brings all the bold flavors of traditional pizza into a hearty, oven-baked dish that satisfies the whole family. This easy-to-prepare comfort food classic is loaded with cheesy goodness, rich marinara, savory pepperoni, and perfectly baked pasta or biscuit dough. It’s ideal for busy weeknights, game days, and potlucks.
Ingredient Breakdown for the Perfect Pizza Casserole
| Ingredient | Quantity | Purpose |
|---|---|---|
| Pasta (penne or rotini) | 12 oz | Acts as the casserole base |
| Marinara or Pizza Sauce | 2 cups | Rich tomato flavor |
| Mozzarella Cheese | 2 cups (shredded) | Melty topping and filler |
| Pepperoni | 1.5 cups | Bold, spicy bites |
| Italian Sausage | 1 lb (optional) | Adds protein and depth |
| Parmesan Cheese | 1/2 cup | Sharp finish |
| Green Bell Pepper | 1 (diced) | Adds freshness and crunch |
| Red Onion | 1/2 (sliced) | Slight sweetness |
| Olive Oil | 1 tbsp | For sautéing |
| Garlic | 3 cloves (minced) | Enhances umami |
| Italian Seasoning | 2 tsp | Balanced herb flavor |
| Red Pepper Flakes | 1/2 tsp (optional) | Heat boost |
| Salt & Pepper | To taste | Seasoning base |
Step-by-Step Instructions
Step 1: Boil Pasta
Cook pasta in salted water until just al dente (about 1–2 minutes under recommended time). Drain and set aside.
Step 2: Cook the Protein & Veggies
In a skillet, heat olive oil and sauté garlic, onions, and bell pepper. Add Italian sausage (if using), cooking until browned. Drain excess fat.
Step 3: Layer Flavors
In a large mixing bowl, combine:
- Cooked pasta
- Marinara sauce
- Sautéed mixture
- Half of the mozzarella
- Half of the pepperoni
- Italian seasoning and pepper flakes
Mix until well combined.
Step 4: Assemble the Casserole
In a 9×13 baking dish:
- Spread the pasta mixture evenly
- Top with remaining mozzarella, pepperoni, and Parmesan
Step 5: Bake
Bake uncovered at 375°F (190°C) for 25–30 minutes until cheese is golden and bubbling.
Step 6: Rest and Garnish
Let rest for 5 minutes before slicing. Garnish with fresh basil or chopped parsley if desired.
Optional Variations for a Custom Pizza Bake
- Crust-style version: Use canned biscuit dough or pizza dough in place of pasta for a “deep-dish pizza casserole” feel.
- Low-carb version: Substitute pasta with cauliflower florets or zucchini spirals.
- Vegetarian: Omit sausage and use black olives, mushrooms, or artichokes.
- Kid-friendly: Add mini pepperonis and hide in some finely chopped spinach.
Nutrition Information (Approximate Per Serving)
| Nutrient | Amount |
|---|---|
| Calories | 540 kcal |
| Protein | 26g |
| Carbohydrates | 40g |
| Fat | 28g |
| Saturated Fat | 12g |
| Sodium | 980mg |
Storage and Reheating Guidelines
- Refrigeration: Store in airtight containers for up to 4 days.
- Freezing: Freeze unbaked casserole tightly wrapped for up to 2 months. Thaw overnight and bake as directed.
- Reheating: Microwave individual portions or reheat covered in oven at 350°F for 15–20 minutes.
Recommended Side Dishes
- Garlic knots or Texas toast
- Caesar salad or garden greens
- Roasted broccoli or green beans
- Sparkling lemonade or a glass of Chianti
Frequently Asked Questions
Can I use pre-cooked meat?
Yes. Rotisserie chicken, cooked sausage, or leftover beef all work well in this dish.
Do I have to use pepperoni?
Not at all. Substitute with Canadian bacon, turkey pepperoni, or go meatless.
Can I prep this ahead?
Absolutely. Assemble the full dish, cover, and refrigerate up to 24 hours before baking.
Homemade Marinara Recipe (Optional)
**Quick Marinara Sauce**
- 1 tbsp olive oil
- 1 clove garlic, minced
- 1 can (28 oz) crushed tomatoes
- 1 tsp dried oregano
- Salt and pepper to taste
Simmer all ingredients on low for 20 minutes. Optional: add 1 tsp sugar for balance.
Summary
This Pepperoni Pizza Casserole is the ultimate easy comfort food for families, parties, and anyone craving the irresistible flavor of pizza in a pasta bake format. Packed with melted cheese, savory pepperoni, bold spices, and customizable ingredients, it’s a guaranteed crowd-pleaser. Make it ahead, freeze it, or serve it fresh—either way, it’s a new weeknight staple.